Key to the Table Above

The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.

For each experiment, information is included on species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, dose level(s) in mg/kg body weight/day, and duration of experiment; experimental results are provided on target organ, tumor type, and tumor incidence; carcinogenic potency (TD₅₀) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation.

Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. Only routes of administration with whole body exposure are included. Doses are standardized, average dose rates in mg/kg/day. A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD₅₀ estimation for a standard lifespan. See Methods for other details.

TD₅₀ provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD₅₀ values across chemicals that are rodent carcinogens is more than 100 million-fold. More than half the chemicals tested are positive in at least one experiment.

A plot of all results on each experiment in the CPDB for this chemical is presented below. These results are the source information for the Cancer Test Summary table above.

Carbon tetrachloride: All Experiments and Citations in CPDB

The definition of each code in the plot below will appear in a pop-up window when the field name in the header line is clicked, e.g., Strain, Site, Path. Each numbered line starts a new experiment and reports protocol information in black. Average daily dose-rates per kg body weight per day are in green. Remaining lines report experimental results in blue.

Abbreviations of fields in header line: # = the line number in the plot of all CPDB chemicals; Xpo = duration of dosing; Xpt = duration of experiment; Site = tissue; Path = tumor type; DR = dose-response; AuOp = author’s opinion about carcinogenicity; LoConf, UpConf = confidence limits (99%) on TD₅₀; Inc = tumor incidence for each dose group.

See Guide to reading the plot for details on each field, using an example of one experiment.

See Help to improve readability, or to fit the plot onto the screen or a printed page.

Chemical (Synonym) CAS
# Species Sex Strain Route Xpo+Xpt PaperNum        0 Dose  1 Dose 2 Dose  3 Dose          Literature Reference or NCI/NTP:Site Path
Site Path Notes   TD50  DR Pval    AuOp LoConf UpConf   Cntrl   1 Inc  2 Inc   3 Inc                                                        Brkly Code


CARBON TETRACHLORIDE   56-23-5
1105 M f b6c gav 78w90 1469m                         0    774.mg  1.55gm      Weisburger;enhp,21,7-16;1977/National Cancer Institute
                                                                                                                                1976
 liv hpc ej     184.mg * P<.0005 +  119.mg 287.mg   1/18   40/42   43/45
 adr mix ej     899.mg \ P<.0005 +  490.mg 2.35gm   0/18   15/42  (10/45)
 tba mix ej     195.mg * P<.0005    123.mg 324.mg   3/18   40/42   43/45
1106 M m b6c gav 78w90 1469m                         0    774.mg  1.55gm
 liv hpc ej     127.mg * P<.0005 +  70.1mg 220.mg   3/18   49/49   47/48
 adr mix ej     683.mg * P<.0005 +  487.mg 1.21gm   0/18   28/49   28/48
 tba mix ej     130.mg * P<.0005    70.9mg 230.mg   4/18   49/49   47/48
1107 M f bdj inh 24m24 2378                          0    9.84mg  49.2mg  246.mg                 Nagano;apor,741-746;1998/pers.comm.
 liv mix e      25.2mg * P<.0005 +  17.1mg 38.9mg   4/50    9/49   44/50   48/49
 liv hpc e      41.9mg Z P<.0005 +  27.0mg 70.5mg   2/50    1/49   33/50  (48/49)
 liv hpa e      85.4mg Z P<.0005 +  46.4mg 265.mg   2/50    8/49   17/50   (5/49)
 adr phe e      377.mg Z P<.0005 +  226.mg 692.mg   0/50    0/49    0/50   22/49
 lun a/c e      46.1gm * P<1.       1.33gm n.s.s.   2/50    2/49    1/50    2/49
 lun a/a e      no dre   P=1.       2.72gm n.s.s.   4/50    2/49    1/50    0/49
1108 M m bdj inh 24m24 2378                          0    8.20mg  41.0mg  205.mg
 liv mix e      15.1mg * P<.0005 +  8.96mg 29.2mg  24/50   20/50   48/50   50/50
 liv hpc e      34.0mg * P<.0005 +  21.1mg 59.8mg  17/50   12/50   42/50   48/50
 liv hpa e      50.2mg Z P<.0005 +  28.1mg 135.mg   9/50    9/50   27/50  (16/50)
 adr phe e      126.mg * P<.0005 +  86.8mg 190.mg   0/50    0/50   16/50   31/50
 lun a/a e      no dre   P=1.       1.68gm n.s.s.   2/50    5/50    1/50    1/50
 lun a/c e      no dre   P=1.       48.2mg n.s.s.  11/50    4/50   (3/50    0/50)
1109 R f f3d inh 24m24 2378                          0    2.34mg  11.7mg  58.6mg
 liv mix e      29.8mg Z P<.0005 +  20.3mg 45.6mg   0/50    0/50    3/50   44/50
 liv hpa e      38.7mg Z P<.0005 +  25.9mg 61.0mg   0/50    0/50    0/50   40/50
 sub mix e      65.2mg Z P<.003     28.2mg 329.mg   0/50    1/50    6/50   (0/50)
 liv hpc e      120.mg * P<.0005 +  68.9mg 236.mg   0/50    0/50    3/50   15/50
 adr phe e      no dre   P=1.       148.mg n.s.s.   8/50   12/50   19/50   10/50
 adr mix e      no dre   P=1.       155.mg n.s.s.   9/50   12/50   20/50   10/50
1110 R m f3d inh 24m24 2378                          0    1.64mg  8.20mg  41.0mg
 liv mix e      26.0mg Z P<.0005 +  17.4mg 40.8mg   1/50    1/50    1/50   40/50
 liv hpc e      39.1mg Z P<.0005 +  25.2mg 65.1mg   1/50    0/50    0/50   32/50
 liv hpa e      61.8mg * P<.0005 +  37.5mg 112.mg   0/50    1/50    1/50   21/50
1111 R f nss ivj 47w69 1515                          0    .157mg                                  Tourkevitch;ijcn,20,1446-1449;1964
 liv tum        .877mg   P<.1       .265mg n.s.s.   0/34    3/57
 mgl mix        .765mg   P<.3    +  .214mg n.s.s.   1/34    5/57
 tba mix        .176mg   P<.007     87.0ug 2.27mg   2/34   16/57
1112 R f osm gav 18m26 1469n                         0    40.5mg  81.0mg      Weisburger;enhp,21,7-16;1977/National Cancer Institute
                                                                                                                                1976
 liv nnd ej     390.mg * P<.3    +  140.mg n.s.s.   1/20   11/50    9/49
 liv hpc ej     no dre   P=1.       415.mg n.s.s.   1/20    4/50    2/49
 tba mix ej     no dre   P=1.       144.mg n.s.s.  10/20   34/50   20/49
1113 R m osm gav 18m26 1469n                         0    23.8mg  47.6mg
 liv nnd ej     529.mg * P<.2    +  201.mg n.s.s.   0/20    2/49    3/50
 liv hpc ej     666.mg * P<.4       230.mg n.s.s.   0/20    2/49    2/50
 tba mix ej     166.mg * P<.4       48.7mg n.s.s.   7/20   21/49   24/50

See full CPDB Summary Table on 1547 chemicals. See Full CPDB for all results on 6540 experiments of 1547 chemicals.

A complete list of CPDB chemicals, which is searchable by name or by CAS number, is available here.

For a compendium of CPDB results organized by target organ, which lists all chemicals in each species that induced tumors in each of 35 organs, see Summary Table by Target Organ.

The CPDB is available in several formats that permit printing and downloading into spreadsheets and statistical databases.

1. A plot of the CPDB presents results of 1547 experiments on 6540 chemicals in an easily readable format that has been used in publications of the CPDB.
2. A Screen version plot for use on a single computer screen, with the same data.
3. Excel version of the same data.
4. Tab-separated versions of the same data, which can be easily read into databases.

A Supplementary Dataset gives details on dosing and survival for each experiment.

Relatively precise estimates of the lower confidence limit on the TD₁₀ (LTD₁₀) are readily calculated from the TD₅₀ and its lower confidence limit, which are reported in the CPDB. For researchers and regulatory agencies interested in LTD₁₀ values, we provide them in an Excel spreadsheet.

PDF versions of our publications of analyses using the CPDB are available, organized by year and by research topic.